Transformation, identity, fate, destiny, crime, and punishment are some of the fascinating themes that are unraveled for readers in the Bookclub-in-a-Box discussion guide for Jeffrey Eugenides' Pulitzer Prize winning novel, Middlesex. The guide looks at the central character Callie, a hermaphrodite, and fits her unusual story against an historic and cultural backdrop which includes Detroit in the 1930's, prohibition, silk-making, myths, legends and Greek tragedy. Bookclub-in-a-Box illustrates how Eugenides takes this heart-wrenching, but not uncommon situation, and presents it with respect, sympathy and dignity. As a reader, they will gain a deeper understanding and insight into the complex layers of this riveting story: